Windows Server 2012 Login Issue “The User Profile Service service failed the sign-in. User profile cannot be loaded.”

Problem:

When you log in you get an error that says the user profile service failed the sign on because the user profile cannot be loaded.

Resolution:

This typically happens because of a permissions issues on the Default folder.

1. Browse to the folder by heading to \\SERVERNAME\C$\Users\Default
2. Right click the folder and go to Security > Advanced
3. From there, check the box at the bottom that says “Replace all child permission entries with inheritable permission entries from this object.”

Here’s a screenshot of that box:

That should take care of it. Let me know if this works for you.

Cheers!